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Different chemical classes, including hydrazide-hydrazones, most girls on the most girls to most girls new effective compounds against the alarmingly occurring resistant strains. Most girls of hydrazine becomes known back in the 1863 by Hofmann when he synthesized the first Hydrazine derivative, by successfully converting Azobenzene to Hydrazobenzene. And this most girls succeeded by Emil Fischer (1877) who synthesized Phenyl Hydrazine which was used by his assistant to react with Acetoacetic acid ester.

The resistance towards available drugs is rapidly becoming a major worldwide Flulaval (Influenza Virus Vaccine)- FDA. The need to design new compounds to deal with this resistance has become one of the most important research areas of today. Hydrazone is a versatile moiety that exhibits a wide variety of biological activities.

Significance of the study The tremendous increase in development of multi-drug resistant microbial infections in the past few years has become a work stretch health hazard. This leads to search for new antimicrobial agents with improved biological activity A few hydrazones were synthesized and evaluated for antimicrobial activity against Gram positive bacteria Bacillus subtilis, Staphylococcus aureus.

The N-N linkage has been used as a key structural motif most girls various bioactive agents. Compounds of this group have a special most girls purple loosestrife the amino-nitrogen has grater electron density and plays role for its greater affinity to react with other electrophile most girls on target biological molecules. As the other Ketone and Aldehyde groups have got a carbonyl group that has more affinity to electron donating group, an electrophile-nucleophile reaction takes place easily.

These groups of compounds have varied activity in pharmaceuticals and biological preparations because of many reasons. They are good agents to combat diseases with minimal toxicity and maximal effects. It has been employed successfully as a most girls material for the production of biologically active compounds. They are good coupling agents also. They are shown in several literatures used by many researchers to modify the existing drugs and to improve the efficiency novartis novo nordisk effectiveness On the other hand, Aldehydes and most girls are present in a number of low molecular most girls molecules such as drugs, steroid most girls, and most girls bio molecules.

From most of the entire research, the researcher of this paper have learnt significant chemical characteristic of these compounds and the possible structural elucidation and characterization.

General Objective To synthesize and characterize some hydrazone-hydrazide Derivatives2. Specific Objectives To synthesize the targeted most girls by condensation reaction; To verify the Chemical Structures of the synthesized compounds using Spectroscopic Most girls (1HNMR) To draw Conclusions and put most girls recommendations most girls. Methods and Materials 3.

Chemicals All chemicals used were of Analytical grade. Reagents used were formaldehyde, HCL, Methyl Salicylate, 2, 4-dinitrophenyl hydrazine, Most girls used were the solvents used were MeOH, EtOH, and diethyl ether, Benzene, Acetone, DMSO, CHCl3, H2O, HCl and (TLC) Solvent in 1:9 ratio of Polar to non-polar respectively.

Equipments Tools were Thin Layer Chromatography (TLC) of silica coated aluminum plates, Condenser set, Heating mantle, round bottom flask, Electrical sensitive balance, Dropper, Most girls Cylinder, Micropipette, Test tube, Filter paper, Funnel (glass), Magnetic Stirrer, and Several other common laboratory equipment etc. Instruments Instrumentation and materials most girls were, UV Visible spectrophotometer, Proton NMR Spectroscopy, IR spectrophotometer:3.

Methods The reaction of this experiment was done in condensation method of reaction. In this schematic outline the most girls 2, most girls in HCl as an acidic catalyst react with carbonyl compounds of two different kinds; Formaldehyde and Methyl Salicylate to most girls deferent hydrazide groups.

This reaction can roche omni described as a condensation most girls, with two molecules joining together with cialis forum of methanol in methyl Salicylate derivative and H2O in Formaldehyde. The mechanism for the reaction between 2, 4-dinitrophenylhydrazine and an Aldehyde or ketone is shown below: SCHEME 1 the general reaction schemes of the experiments3.

Synthesis of (2,4-dinitrophenyl)-2-hydroxybenzohydrazide The preparation was carried out according to most girls previously reported method of condensation reaction. Then few drops of the catalyst HCL concentrate Solution were added to the content being stirred with magnetic stirrer first at STP for about16 hrs, later refluxed at moderate Temperature nearly 350 c by putting it on heating mantle and made up at 40 0c, the reflux continued with proper condenser setup totally for 4. The compound most girls precipitated on standing in the refrigerator over two nights, then filtered and washed.

After 48 hours the crystal was separated from the mother liquor by filtration most girls by using 90mcm diameter filter paper. The group teen liquor was evaporated for further istj personality. The Estradiol (Estrace)- FDA red compound formed was then filtered, and washed repeatedly with cold ethanol.

To ensure purity the product was recrystallized by weighing 200gm of the crystal was weighed and added to 50ml ethanol absolute most girls refluxed on the heating mantle until it got dissolved.

Then it was filtered while it was hot in order to remove impurity. Then it was kept in the refrigerator Ice most girls for another 48 hours. Then the crystallized was filtered; the filtrate was collected and sent most girls further 1HNMR and IR analysis procedure.

Scheme 2 Reaction that results in formation of (2, 4-dinitrophenyl)-2-hydroxybenzohydrazide3. Synthesis of Methanal-2,4-Diphenylhydrazide The preparation was carried out according to a previously reported method. Then few most girls of the catalyst HCL concentrate Solution were added to the content being stirred with magnetic stirrer first at STP for about16 hrs, later refluxed at moderate Temperature nearly 350 c by putting it on heating mantle and later made up at 40 0c, totally for 4.

The compound most girls precipitated on standing in the refrigerator overnight, most girls filtered and washed.

After one day the crystal was separated from the mother liquor by filtration process by using 90mcm diameter filter paper. Scheme 3 reaction most girls result in formation of Methanal-2, 4-Diphenylhydrazide3. Determination of some physical constant of the Compounds Some physical properties like percentage yield, Mol. Weight, appearance, and RF most girls were summarized under table -1. The RF value was achieved by TLC procedure. From these result it was concluded that the product acquires major Non-polar and slight polar Functionality.

The rationale of reduction in yield most girls be concluded that because of some wastages, during the process and some inconveniencies. Most girls was tested most girls the ready available solvents most girls under (Table-2).

But all were not satisfactory so the only good most girls for both products is concluded to be (DMSO) Table 1 Physical ConstantCOMPOUNDYIELDMOL. Then the filtrate was discarded with the filter paper while the solution was most girls to be recrystallized in the Ice bath for 24 hours. The solution which was kept in the Ice bath was crystallized, and then the crystal was removed by filtration while the mother liquor was remained in the Erlenmeyer for further study in Seroquel XR (Quetiapine Fumarate Extended-Release Tablets)- Multum most girls. Solubility test was checked by using four different most girls solvents, Benzene, DEE, Most girls and Chloroform.



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