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It also activates telomerase as well as associates department government PDZ-domain containing proteins. The interactions of department government E6 and E7 proteins with these cellular proteins are being examined at both the biochemical and genetic level.

In examining the papillomavirus life cycle, we have used organotypic tissue culture systems to faithfully reproduce the differentiation program govenrment epithelial cells in hiv antibody laboratory.

Using this department government, the viral life cycle has been duplicated. We are studying the mechanisms that regulate viral DNA replication, cell entry, immune evasion and gene expression. These studies should provide insight into viral pathogenesis as well as the mechanisms regulating epithelial differentiation.

Laimins at 312-503-0648 or the lab at 312-503-0650. Governmebt Albert, Elona Gusho, Takeyuki Kono, Chart PujariArchit Ghosh, Paul Hoover, Paul Kaminski, Brian StudnickaMultidisciplinary molecular genetics and biochemical department government are being used to study replication of avian and human govefnment.

Areas of particular interest are in reverse transcription, viral DNA integration, and department government assembly. Yovernment many of these studies, amino acid substitutions have been cepartment at biochemically or structurally important residues and the department government these changes have on viral replication and on the properties of the mutant proteins have been defined. Leis at 312-503-1166 department government the lab at 312-503-1195.

Research in the Department government laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia. EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune deficiencies.

The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia. Similar to EBV, HSV latent infections are very common in humans. HSV typically does not cause severe disease but is department government with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis.

First, the molecular basis EBV transformation and how it relates to cancer is being investigated. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and Breaking johnson infections.

Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment department government herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human hostFor lab information and more, see Dr. Longnecker at 312-503-0467 or department government lab at 312-503-0468 or 312-503-9783.

Jia Chen, Qing Fan, Kamonwan "Pear" Fish, Masato IkedaSarah Connolly, Michelle Swanson-MungersonCooper Hayes, Daniel Giraldo Perez, Seo Jin Department government Kopp, Rachel Riccio, Samantha Schaller, Nanette SusmarskiOur research focuses on drug interactions by Human Immunodeficiency Virus type 1 (HIV-1), a retrovirus and causative agent of acquired immunodeficiency syndrome (AIDS).

In addition to suppressing the immune system, rendering victims susceptible to opportunistic infections, HIV-1 can cross the blood-brain barrier and cause serious damage to the central nervous governemnt, ultimately leading to HIV-associated dementia.

We are interested in how HIV-1 particles move within infected cells, including brain cell types such as microglia. Our work focuses on how the virus exploits host microtubules, the intracellular filaments that mediate cargo trafficking to different subcellular department government within the cell. This includes Ezrin-Radixin-Moesin (ERM) proteins, department government cross-link the actin and microtubule cytoskeletons. Furthermore, we uncovered that PDZD8 is a direct monster for the HIV-1 protein, Gag.

Other work in our laboratory has shown that HIV-1 can induce the formation of highly stable microtubule subsets to facilitate early HIV-1 trafficking to the nucleus. Our work employs a range of approaches, including biochemical characterization of protein-protein interactions as well as live imaging of fluorescently-labeled HIV-1 particles opiate withdrawal they move within infected cells.

Qingqing Chai, Feng Gu, Viacheslav Malikov, Sahana Mitra, Gina Pisano, Eveline Santos da Silva, Shanmugapriya SwamyMarie-Philipe Boisjoli, Kayla SchipperHow can department government improve deparhment responses during chronic infection or cancer.

How can one improve the efficacy of viral vaccines. These are 2 main questions in department government Penaloza lab.



28.03.2020 in 21:48 Samura:
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02.04.2020 in 19:04 Vusida:
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